The Influence of Flaxseed on the body weight of Wistar Ovarioctomized Rats
DOI:
https://doi.org/10.13037/rbcs.vol13n43.2433Keywords:
Nutrição, sementes de linhaça, ovariotomia, efeitos hormonaisAbstract
Objectives: To evaluate the influence of flaxseed for a long period of time and its hormonal effects of weight loss in castrated rats. Methods: We used 21 Wistar rats that underwent bilateral oophorectomy for induction of menopause, randomly divided into three groups: control group (CG) (n = 7), which received a diet based on casein 10 percent; flaxseed group, that received a diet based on casein plus 25 percent of flaxseed (FG) (n = 7); and modified control group, that received a diet based on modified casein 10 percent and with addition of lipid and fibers (CGM) (n = 7). All diets were prepared according to the recommendations of the AIN 93, the animals were kept under controlled temperature (22ºC ±2ºC) and adequate lighting (light/dark cycle of 12 to 12 hours). The animals received food and water (adlibitum). The rats were anesthetized with Thiopentax® for blood collection by cardiac puncture for the determination of 17b-estradiol and collection of tissues (liver, bladder and uterus).Downloads
References
1. Canadian Grains Comission. Canada Western Flaxseed an
of Yellow Flaxseed Samples. 2001. Disponível em: www.
Grainsscanada.dc.ca. Acesso em 10.10.2013.
2. Dodin S, Lemay A, Jacques H, Légare F, Forest J-C, Maassê,
B. The effects of flaxseed dietary supplement on lipid profile,
bone mineral density and symptoms in menopausal womem:
a randomized doube-blind wheat germ placebo-controled
clinical trial. J. Clin Endocrinol Metab. 2005;90(3):1390-7.
3. Lucas EA, Lightfoot SA, Hammond LJ, Devareddy
L, Khalil DA, Daggy BP, et al. Flaxseed reduced plasma
cholesterol and atherosclerotic lesion formation in
ovariectomized golden Syrian hamsters. Atherosclerosis.
2004;173(2):223-9.
4. Dalais FS, Rice GE, Walhlqvist ML, Grehan M, Murkies
AL, Medley G, et al. Effects of dietary phytoestrogens in
postmenopause women. Climateric.1998;1(2):124-9.
5. Morris DH. Essential nutrients and other functional compounds
in flaxseed. Nutr Today. 2001;36(3):159-62.
6. Armaganijan D, Batlouni M. Impacto dos fatores de risco
tradicionais. Rev Soc Cardiol. 2000;10(6):686-93.
7. Wang L, Chen J, Thompson LU. The inhibitory effect of
flaxseed on the growth and metastasis of estrogen receptor
negative human breast cancer xenograftsis attributed
to both its lignan and oils component. Int J Cancer.
2005;116(95):793-8.
8. Claupach R., Meirelles RMR, Julião MASG, Loureiro
CKC, Giarodoli PB, Pinheiro SA, et al. Fitoestrogênicos:
Posicionamento do Departamento de endocrinologia
Feminina da Sociedade Brasileira de Endocrinologia
e Metabologia (SBEM). Arq Bras Endocrinol Metab.
2002;46(6):679-95.
9. Begum NA, Nicole C, Milla I, Lapierre C, Nagano K, et al.
Dietary Lignins precursor of mammalian lignans in rats. J
Nutr. 2003;134(1):120-7.
10. Hu C, Yuan YV, Kitts DD. Antioxiant activities of the
flaxseed lignan secoisolariciresinol diglucoside, its aglycone
ecoisolariciresinol and the mammalian lignans
enteroldiol and enterolactone in vitro. Food and Chem Tox.
2007;45:2219-27.
11. Rickets ML, Moore DD, Banz WJ, Mezei O, Shay NF.
Molecular mechanism of action of the soy isoflavones includes
activation of promiscuous nuclear receptors: a review. J
Nutr Biochem. 2005;16(6):321-30.
12. Richard SE, Orcheson LJ, Seidl MM, Luyengi L, Fong
HH, Thompson LU. Dose-dependent production of
mammalian lignans in rats and in vitro from the purified
precursor secoisolariciresinol diglycoside in flaxseed. J
Nutr.1999;126(8):2012-19.
13. Branca F, Lorenzetti S. Health Effects Of Phytoestrogens.
Forum Nutr Italia. 2005;57:100-111.
14. Guerra TRB, Boaventura GT, Vellarde CLG.
Phytoestrogens the modulador selective receptor estrogen?
Rev Bras Pesqui Méd Biol. 2011;10(1):67-70.
15. Hutchins AM, Slavin JL. Effects of flaxseed on sex hormones
metabolism. In: Thompson LU, Cunnane SC,
editors. Flaxseed in human nutrition. 2ª ed. Champaign:
AOCS Press; 2003. p. 126-49.
16. Pardridge WM, Mietus LJ. Transport of Steroid Hormones
through the Rat Blood-Brain Barrier. J Clin Invest. 1979
Jul;64(1):145-54.
17. Ruggiero R, Likis FE. Estrogen: physiology, pharmacology,
and formulations for replacement therapy. J of Midwifery
& Womens Health. 2002;47(3):130-8.
18. Puig-Duran E, Greenstein BD, MacKinnon PCB. Effects
of serum o estrogen-binding components on the unbound
oestradiol-17ß fraction in the serum of developing female
rats and on inhibition of [3H]oestradiol uptake by uterine
tissue in vitro. J Reprod Fert. 1979;56(2):707-14.
19. Ghiselli G, Jardim WF. Interferentes Endócrinos no ambiente.
Química Nova. 2007;30(3): 695-706.
20. Hulley S, Grady D, Bush T, Furberg C, Herrington D,
Riggs B, et al. Randomized trial of estrogen plus progestin
for secondary prevention of coronary heart disease in postmenopausal
women. JAMA. 1998;280(7):650-13.
21. Tremolliéres FA, Pouilles JM, Ribot CA. Relative influence
of age and menopause on total and regional body composition
changes in postmenopausal women. Am J Obstet
Gynecol. 1996;175(6):1594-600.
22. Buss C, Nunes MA, Camey S, Manzolli P, Soares RM,
Drehmer M, et al. Dietary fibre intake of pregnant women
attending general practices in southern Brazil – the
ECCAGE study. Public Health Nutr. 2009;12(9):1392-8.
23. Shoppen S, Acarbajal A, Pérez-Granados AM, Vivas F,
Pilar Vaquero M. Food energy and macronutrient intake of
postmenopausal women from a menopause program. Nutr
Hospitalaria. 2005;20(2):101-9.
24. Botsis D, Christodoulakos G, Papagianni V, Lambrinoudaki
I, Aravantinos L, Makrakis E, et al. The effect of raloxifene
and tibolone on the uterine blood flow and endometrial
thickness: a transvaginal Doppler study. Maturitas.
2006;53(3):362-8.
INFLUÊNCIA DA SEMENTE DE LINHAÇA SOBRE O PESO RELATIVO CORPORAL DE RATAS WISTAR OOFORECTOMIZADAS 17
Revista de Atenção à Saúde, v. 13, no 43, jan./mar. 2015, p.11-17
25. Biondo-Simões MLP, Zimmermann E, Daher TS, Borsato
KS, de Noronha L. Effects of hormonal replacement therapy
on colon anastomosis healing in rats. Acta Cir Bras.
2005;20(3):237-42.
26. Miller O. O laboratório para o clínico. 3ª ed. São Paulo:
Atheneu; 1977.
27. Mikkola TS, Clarkson TB. Estrogen replacement therapy,
atherosclerosis and vascular function. Cardiovasc Res.
2002;53(3):605-19.
28. Jenkins DJ, Kendall CW, Vidgen E, Agarwal S, Rao AV,
Rosenberg RS, et al. Health aspects of partially defatted flaxseed,
including effects on serum lipids, oxidative measures,
and ex vivo androgen and progestin activity: a controlled
crossover trial. Am J Clin Nutr. 1999;69(3):395-402.
29. Lemay A, Dodin S, Kadri N, Jacques H, Forest JC. Flaxseed
dietary supplement versus hormone replacement therapy in
hypercholesterolemic menopausal women. Obstet Gynecol.
Sep 2002;100(3):495-504.
30. Lucas EA, Wild RD, Hammond LJ, Khalil DA, Juma S,
Daggy BP, et al. Flaxseed improves lipid profile without altering
biomarkers of bone metabolism in postmenopausal
women. J Clin Endocrinol Metab. 2002;87(4):1527-32
31. Soares LL, Pacheco JT, Brito CM, Troina AA, Boaventura
GT, Guzman-Silva MA. Avaliação dos efeitos da semente de
linhaça quando utilizada como fonte de proteína nas fases
de crescimento e manutenção em ratos. Rev Nutr. 2009;
22(4):483-91.
32. Lissin DV, Gomperts SN, Carroll RC, Christine CW,
Kalman D, Kitamura M, et al. Activity differentially
regulates the surface expression of synaptic AMPA and
NMDA glutamate receptors. Proc Natl Acad Sci USA.
1998;95(12):7097-102.
33. Lemay A, Dodin S, Kadri N, Jacques H, Forest JC. Flaxseed
dietary supplement versus hormone replacement therapy in
hypercholesterolemic menopausal women. Obstet Gynecol.
2002;100(3): 495-504.
34. Silva MR, Silva MAAP. Aspectos nutricionais de fitatos e
taninos. Rev Nutr. 1999;12(1):21-32.
35. Wannmacher L, Reiner RL. Reposição hormonal na menopausa:
questão ainda polêmica. Boletim da Sociedade
Brasileira de Vigilância de Medicamentos. 1998;30:5-8.
36. Bhathena SJ, Velasquez MT. Beneficial role of dietary
phytoestrogens in obesity and diabetes. Am J Clin Nutr.
2002;76(6):1191-201.
37. Geary N, Asarian L. Cyclic estradiol treatment normalizes
body weight and test meal size in ovariectomized rats.
Physiol Behav. 1999;67(1):141-7.
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